Малые ядрышковые РНК: различия между версиями

[отпатрулированная версия][отпатрулированная версия]
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The majority of vertebrate snoRNA genes are encoded in the introns of proteins involved in ribosome synthesis or translation, and are synthesized by RNA polymerase II, but snoRNAs can also be transcribed from their own promoters by RNA polymerase II or III.
 
== Другие функции мякРНК ==
== Other functions of snoRNA ==
Recently,Недавно itбыло hasобнаружено, beenчто foundмякРНК thatимеют snoRNAs can have functionsфункции, notне relatedсвязанные toс rRNAрРНК. OneОдна suchиз functionтаких isфункций theсостоит regulationв ofрегуляции [[alternativeальтернативный splicingсплайсинг|альтернативного сплайсинга]] of the ''transтранс'' gene transcript-транскриптов{{термин?}}, whichосуществляемой isмякРНК doneпод by the snoRNAназванием [[Small nucleolar RNA SNORD115|HBII-52]] (SNORD115).<ref name=Kishore> {{cite journal | author = Kishore S, Stamm S | year = 2006| title = The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C | journal = Science | volume = 311| issue = 5758 | pages = 230–231 | pmid = 16357227| doi = 10.1126/science.1118265 }} </ref>
 
Recently, it has been found that snoRNAs can have functions not related to rRNA. One such function is the regulation of [[alternative splicing]] of the ''trans'' gene transcript, which is done by the snoRNA [[Small nucleolar RNA SNORD115|HBII-52]].<ref name=Kishore> {{cite journal | author = Kishore S, Stamm S | year = 2006| title = The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C | journal = Science | volume = 311| issue = 5758 | pages = 230–231 | pmid = 16357227| doi = 10.1126/science.1118265 }} </ref>
 
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