Интегрин альфа-M: различия между версиями
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Addbot (обсуждение | вклад) м Перемещение 3 интервики на Викиданные, d:q3799301 |
Эрг (обсуждение | вклад) Нет описания правки |
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{{GNF_Protein_box
| Name = Интегрин альфа-M
| image = Protein_ITGAM_PDB_1bho.png
| image_source = {{PDB2|1BHO}}
| PDB = {{PDB2|1A8X}}, {{PDB2|1BHO}}, {{PDB2|1BHQ}}, {{PDB2|1IDN}}, {{PDB2|1IDO}}, {{PDB2|1JLM}}, {{PDB2|1M1U}}, {{PDB2|1MF7}}, {{PDB2|1N9Z}}, {{PDB2|1NA5}}, {{PDB2|2LKE}}, {{PDB2|2LKJ}}, {{PDB2|3Q3G}}, {{PDB2|3QA3}}, {{PDB2|4M76}}
| HGNCid = 6149
| MGIid = 96607
| Symbol = ITGAM
| AltSymbols =; CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6
| IUPHAR =
|OMIM=120980▼
| ChEMBL = 3826
▲ | OMIM = 120980
| ECnumber = ▼
| Homologene = 526
▲|ECnumber=
| GeneAtlas_image1 = PBB_GE_ITGAM_205786_s_at_tn.png
| GeneAtlas_image2 =
| GeneAtlas_image3 =
| Protein_domain_image =
| Function = {{GNF_GO|id=GO:0001846 |text = opsonin binding}} {{GNF_GO|id=GO:0001948 |text = glycoprotein binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0043395 |text = heparan sulfate proteoglycan binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0070062 |text = extracellular vesicular exosome}}
| Process = {{GNF_GO|id=GO:0002224 |text = toll-like receptor signaling pathway}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007159 |text = leukocyte cell-cell adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0014005 |text = microglia development}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization}} {{GNF_GO|id=GO:0030593 |text = neutrophil chemotaxis}} {{GNF_GO|id=GO:0034142 |text = toll-like receptor 4 signaling pathway}} {{GNF_GO|id=GO:0045087 |text = innate immune response}} {{GNF_GO|id=GO:0045123 |text = cellular extravasation}} {{GNF_GO|id=GO:0050798 |text = activated T cell proliferation}} {{GNF_GO|id=GO:0050900 |text = leukocyte migration}}
| Hs_EntrezGene = 3684
| Hs_Ensembl = ENSG00000169896
| Hs_RefseqmRNA = NM_000632
| Hs_RefseqProtein = NP_000623
| Hs_GenLoc_db = hg19
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 31271311
| Hs_GenLoc_end = 31344213
| Hs_Uniprot = P11215
| Mm_EntrezGene = 16409
| Mm_Ensembl = ENSMUSG00000030786
| Mm_RefseqmRNA = NM_001082960
| Mm_RefseqProtein = NP_001076429
| Mm_GenLoc_db = mm10
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 128062640
| Mm_GenLoc_end = 128128160
| Mm_Uniprot = P05555
| path = PBB/3684
}}
'''Интегрин альфа-M''' (αM, ''CD11b'') — [[мембранный белок]], гликопротеин из надсемейства [[интегрин]]ов, продукт гена ''ITGAM'', альфа-субъединица интегрина αMβ2 ([[MAC-1]]).
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